Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism

Testicular torsion and subsequent release of reactive oxygen species (ROS) can cause infertility in adults. Oxidative stress following testicular torsion plays an important role in the ýonset and development of apoptotic cell death through dysregulation of the cellular signaling pathways. Anti-inflammatory and antioxidant properties of capsaicin, a bioactive composition present in red peppers, has already been exploited for treatment of the cancer and pain relief. In present work , we evaluated the role of the mammalian target of rapamycin (mTOR) in antioxidant effect of capsaicin against reperfusion injury following testicular torsion.

Source: Theriogenology - March 15, 2018 Category: Genetics & Stem Cells Authors: Nasim Javdan, Seyed Abdulmajid Ayatollahi, Muhammad Iqbal Choudhary, Safaa Al-Hasani, Farzad Kobarfard, Ata Athar, Hamidreza Pazoki-Toroudi Source Type: research