Proliferative and apoptotic changes in the healthy canine endometrium and in cystic endometrial hyperplasia

Proliferation and apoptosis play an important role in cyclic changes in the healthy canine endometrium. Proteins of the Bcl-2-family are known to be involved in the regulation of apoptosis. However, only few reports mention their expression patterns during cystic endometrial hyperplasia (CEH). In order to correlate proliferative and apoptotic processes, expression of the apoptosis-regulatory proteins Bcl-2 (anti-apoptotic) and Bax (pro-apoptotic) in healthy and cystic hyperplastic endometrial tissue as well as in pyometra was investigated.

Source: Theriogenology - March 15, 2018 Category: Genetics & Stem Cells Authors: N. Reusche, A. Beineke, C. Urhausen, M. Beyerbach, M. Schmicke, S. Kramer, A.R. G ünzel-Apel Source Type: research