MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2.

MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2.
Exp Mol Med. 2014;46:e112
Authors: Cheng Z, Ma R, Tan W, Zhang L
Abstract
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed cell proliferation and colony formation and also limited migration and invasion. Fibroblast growth factor 2 (FGF2) was confirmed as a direct target of miR-152. FGF2 knockdown suppressed cell proliferation, colony formation, migration and invasion, whereas FGF2 overexpression partially reversed the suppressive effect of miR-152. Furthermore, the presence of miR-152 was inversely correlated with FGF2 in NSCLC tissues. Overall, this study demonstrated that miR-152 suppressed the proliferation and invasion of NSCLC cells by downregulating FGF2. These findings provide novel insights with potential therapeutic applications for the treatment of NSCLC.
PMID: 25190353 [PubMed - in process]

Source: exp Mol Med - September 7, 2014 Category: Molecular Biology Authors: Cheng Z, Ma R, Tan W, Zhang L Tags: Exp Mol Med Source Type: research