Erythropoiesis, EPO, macrophages, and bone

The regulation of erythropoiesis in the bone marrow microenvironment is a carefully orchestrated process that is dependent upon both systemic and local cues. Systemic erythropoietin (EPO) production by renal interstitial cells plays a critical role in maintaining erythropoietic homeostasis. In addition, there is increasing clinical and preclinical data linking changes in EPO and erythropoiesis to altered skeletal homeostasis, suggesting a functional relationship between the regulation of erythropoiesis and bone homeostasis.

Source: Bone - March 15, 2018 Category: Orthopaedics Authors: Joshua T. Eggold, Erinn B. Rankin Tags: Review Article Source Type: research