Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Human hippocampal neurogenesis drops sharply in children to undetectable levels in adults
Nature 555, 7696 (2018). doi:10.1038/nature25975
Authors: Shawn F. Sorrells, Mercedes F. Paredes, Arantxa Cebrian-Silla, Kadellyn Sandoval, Dashi Qi, Kevin W. Kelley, David James, Simone Mayer, Julia Chang, Kurtis I. Auguste, Edward F. Chang, Antonio J. Gutierrez, Arnold R. Kriegstein, Gary W. Mathern, Michael C. Oldham, Eric J. Huang, Jose Manuel Garcia-Verdugo, Zhengang Yang & Arturo Alvarez-Buylla
New neurons continue to be generated in the subgranular zone of the dentate gyrus of the adult mammalian hippocampus. This process has been linked to learning and memory, stress and exercise, and is thought to be altered in neurological disease. In humans, some studies have suggested that hundreds of new neurons are added to the adult dentate gyrus every day, whereas other studies find many fewer putative new neurons. Despite these discrepancies, it is generally believed that the adult human hippocampus continues to generate new neurons. Here we show that a defined population of progenitor cells does not coalesce in the subgranular zone during human fetal or postnatal development. We also find that the number of proliferating progenitors and young neurons in the dentate gyrus declines sharply during the first year of life and only a few isolated young neurons are observed by 7 and 13 years of age. In adult patients with epilepsy and healthy adults (18–77 year...
Source: Nature - Category: Research Authors: Shawn F. Sorrells Mercedes F. Paredes Arantxa Cebrian-Silla Kadellyn Sandoval Dashi Qi Kevin W. Kelley David James Simone Mayer Julia Chang Kurtis I. Auguste Edward F. Chang Antonio J. Gutierrez Arnold R. Kriegstein Gary W. Mathern Michael C. Oldham Eric Tags: Letter Source Type: research
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