Impaired motility in Barrett's esophagus: A study using high ‐resolution manometry with physiologic challenge

Conclusions & InferencesReduced contractile effectiveness persisted in BE with the more representative esophageal challenge of swallowing solids and free drinking; while in ENRD and FHC peristalsis usually improved, demonstrating peristaltic reserve. Furthermore, symptom association and refluxate clearance were reduced in BE. These factors may underlie BE pathogenesis. Esophageal dysmotility is implicated in the pathogenesis of Barrett's esophagus, but has not been studied following solids and rapid drink challenge, which more accurately replicate normal swallowing behavior. With standard HRM using 5mL water swallows, esophageal body contractility was similarly poor in both Barrett's and endoscopy‐negative reflux disease. When challenged with solids and the rapid drink challenge however, contractility normalized in endoscopy‐negative reflux patients; whereas in Barrett's esophagus it remained just as impaired.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fnmo.13330

Source: Neurogastroenterology and Motility - March 15, 2018 Category: Gastroenterology Authors: S. Sanagapalli, A. Emmanuel, R. Leong, S. Kerr, L. Lovat, R. Haidry, M. Banks, D. Graham, A. Raeburn, N. Zarate ‐Lopez, R. Sweis Tags: ORIGINAL ARTICLE Source Type: research