Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus

Conclusions and InferencesThe generation and propagation of pacemaker potentials by ICC are disrupted via nitric oxide after IM, and this disruption may contribute to POI. When inflammation is ameliorated, ICC can recover their pacemaker function. The participation of interstitial cells of Cajal (ICC) in the postoperative ileus (POI) is not well understood. In a mouse model of POI, the propagation of electrical pacemaker activity and the networks of ICC were disrupted. These changes were mediated by nitric oxide. In addition to smooth muscle and enteric neuron, ICC may be a new therapeutic target cell for prevention and therapeutic management of POI.
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research