Walker ‐256 tumor alters morphology of intestinal myenteric plexus in rats

Conclusions and InferencesThis study showed that the Walker‐256 tumor induced alterations in the morphology of nitrergic and cholinergic neurons in the myenteric plexus and decreased the upper GI transit with the presence of multiple constrictions in the colon. Therefore, these alterations can interfere on neurotransmission and can be related to the intestinal motility alterations observed in tumor‐bearing rats. Gastrointestinal dysmotility is common in patients with cancer, and there are a few studies about the myenteric plexus in the presence of anatomically remote tumors. This study showed that the Walker‐256 tumor induced alterations in the morphology of nitrergic and cholinergic neurons in the myenteric plexus and decreased the upper gastrointestinal transit with the presence of multiple constrictions in the colon. Therefore, these alterations can interfere on neurotransmission and can be related to the intestinal motility alterations observed in tumor‐bearing rats.
Source: Neurogastroenterology and Motility - Category: Gastroenterology Authors: Tags: ORIGINAL ARTICLE Source Type: research