Predictors Of Adverse Outcome In Uterine Smooth Muscle Tumors Of Uncertain Malignant Potential (STUMP): A Clinico ‐pathological Analysis Of 22 Cases With A Proposal For The Inclusion Of Additional Histologic Parameters

ConclusionsThe frequency of adverse outcome in our series (36.4%) was higher than that of previously published reports (7‐16%), suggesting that more stringent criteria can exclude some from further follow‐up. Although “significant” nuclear atypia was not discriminatory, its frequent association with adverse outcome has pathobiological implications. Presence of necrosis was not particularly associated with adverse outcome. Atypical mitoses, epithelioid differentiation, vascular involvement and infiltrative/irregular margins appear to herald adverse outcomes, and therefore merit inclusion into the diagnostic regimen.This article is protected by copyright. All rights reserved.
Source: Histopathology - Category: Pathology Authors: Tags: Original Article Source Type: research