Local partial depletion of CD11b+ cells and their influence on choroidal neovascularization using the CD11b ‐HSVTK mouse model

ConclusionThe CD11b‐HSVTK mouse is a feasible model for a local depletion of CD11b+ cells in the retina. Nevertheless, only a partial depletion of CD11b+ cells could be achieved compared to baseline data without any intravitreal injections. Our results did not reveal a significant reduction in CNV areas. In the light of previous knowledge, the potential influence of systemic immune cells on CNV formation might be more relevant than expected.
Source: Acta Ophthalmologica - Category: Opthalmology Authors: Tags: Original Article Source Type: research