Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues

ConclusionsOur results show that the metabolic disturbances associated with RA depend on the degree of inflammation and identify inflammation of adipose tissue as the initial target leading to IR and the associated molecular disorders of carbohydrate and lipid homeostasis. Thus, we anticipate that therapeutic strategies based on tighter control of inflammation and flares could provide promising approaches to normalize and/or prevent metabolic alterations associated with RA.

Source: Journal of Internal Medicine - March 12, 2018 Category: Internal Medicine Authors: I. Arias de la Rosa, A. Escudero ‐Contreras, S. Rodríguez‐Cuenca, M. Ruiz‐Ponce, Y. Jiménez‐Gómez, P. Ruiz‐Limón, C. Pérez‐Sánchez, M. C. Ábalos‐Aguilera, I. Cecchi, R. Ortega, J. Calvo, R. Guzmán‐Ruiz, M. M. Malagón, E. Collantes Tags: Original Article Source Type: research