Preliminary evaluation of 18F-labeled LLP2A-trifluoroborate conjugates as VLA-4 ( α4β1 integrin) specific radiotracers for PET imaging of melanoma

The transmembrane α4β1 integrin receptor, or very-late antigen 4 (VLA-4), is associated with contributing to tumor metastasis and angiogenesis, the development of chemotherapeutic drug resistance, and is overexpressed in multiple myelomas, osteosarcomas, lymphomas, leukemias, and melanomas. The peptidomimetic, LLP2 A, is a high-affinity ligand with specificity for the extracellular portion of VLA-4 and several conjugates have been evaluated in vivo by NIR-fluorescence, 111In-SPECT and 68Ga- and 64Cu-PET imaging, but to date, not with 18F-PET.

Source: Nuclear Medicine and Biology - March 12, 2018 Category: Nuclear Medicine Authors: Áron Roxin, Chengcheng Zhang, Sungjoon Huh, Mathieu L. Lepage, Zhengxing Zhang, Kuo-Shyan Lin, François Bénard, David M. Perrin Source Type: research