Structure and substrate specificity of β‐ketoacyl‐acyl carrier protein synthase III from Acinetobacter baumannii

This article is protected by copyright. All rights reserved. Acinetobacter baumannii has a novel β‐ketoacyl‐acyl carrier protein synthase III (KAS III), which can accept longer fatty acyl‐CoAs and can feed into de novo fatty acid synthesis. This feature is clinically important as hosts' free fatty acids can be acquired and utilized by pathogens. The crystal structure of A. baumannii KAS III reveals a network of hydrogen bonds (His291‐Asn314) and substitution of residues in the active site cavity to accommodate octanoyl‐CoA.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research