A Trithiol Bifunctional Chelate for 72,77As: a Matched Pair Theranostic Complex with High in vivo Stability
Trithiol chelates are suitable for labeling radioarsenic (72As: 2.49 MeV β+, 26 h; 77As: 0.683 MeV β−, 38.8 h) to form potential theranostic radiopharmaceuticals for PET imaging and therapy. To investigate the in vivo stability of trithiol chelates complexed with no carrier added (nca) radioarsenic, a bifunctional trithiol chelate was developed, and conjugated to bom besin(7-14)NH2 as a model peptide.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Yutian Feng, Anthony J. DeGraffenreid, Michael D. Phipps, Tammy L. Rold, Nkemakonam C. Okoye, Fabio A. Gallazzi, Charles L. Barnes, Cathy S. Cutler, Alan R. Ketring, Timothy J. Hoffman, Silvia S. Jurisson Source Type: research
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