Oligoadenylate synthetase 3 S381R gene polymorphism is associated with severity of EV71 infection in Chinese children

Enterovirus 71 (EV71) is a positive-sense RNA virus belonging to species Enterovirus A, and is a member of family Picornaviridae. Since it was first isolated from stool specimen in a child with central nervous system in 1969, a large outbreak of EV71 infections have occurred across the Asia-Pacific region, causing great economic and social burden [1 –4]. Compared with other enteroviruses, EV71 can cause fatal neurological complications because of its neurotropism [5]. There is a quantity of evidence for the major role of sympathetic hyperactivity and inflammatory responses in the earliest stages of EV71 infections [6–8].

Source: Journal of Clinical Virology - February 3, 2018 Category: Virology Authors: Yedan Liu, Peipei Liu, Shihai Liu, Ya Guo, Hongfang He, Chengqing Yang, Jie Song, Na Zhang, Jianguo Cheng, Zongbo Chen Source Type: research