Diabetes ‐induced colonic slow transit mediated by the up‐regulation of PDGFRα+ cells/SK3 in streptozotocin‐induced diabetic mice

Conclusions and InferencesThese results suggest that the purinergic neurotransmitters/P2Y1/SK3 signaling pathway is up‐regulated in the diabetic colons, thereby mediating diabetes‐induced colonic slow transit. This article investigates the contributions of PDGFRα+ cells to diabetes‐induced colonic slow transit in streptozotocin‐induced diabetic mice. The colonic smooth muscles were more sensitive to apamin (the SK3 antagonist) in STZ‐treated mice, indicating that the functionally up‐regulated SK3 channels exerted more inhibitory effects on the colonic motility.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fnmo.13326

Source: Neurogastroenterology and Motility - March 9, 2018 Category: Gastroenterology Authors: N. ‐N. Song, H.‐L. Lu, C. Lu, L. Tong, S.‐Q. Huang, X. Huang, J. Chen, Y.‐C. Kim, W.‐X. Xu Tags: ORIGINAL ARTICLE Source Type: research