In vitro combination of voriconazole with micafungin against azole-resistant clinical isolates of Aspergillus fumigatus from different geographical regions

In vitro interaction of voriconazole with micafungin was evaluated against 33 clinical Aspergillus fumigatus isolates, including azole-resistant (n=31) and –susceptible (n=2) isolates. Interaction was synergistic for only one resistant isolate carrying the TR34/ L98H mutation. No antagonistic effects were observed for 96.8% of azole-resistant isolates.
Source: Diagnostic Microbiology and Infectious Disease - Category: Microbiology Authors: Tags: Note Source Type: research