Empirical reproducibility, sensitivity, and optimization of acquisition protocol, for Neurite Orientation Dispersion and Density Imaging using AMICO

Neurite Orientation Dispersion and Density Imaging (NODDI) has been gaining prominence for estimating multiple diffusion compartments from MRI data acquired in a clinically feasible time. To establish a pathway for adoption of NODDI in clinical studies, it is important to understand the sensitivity and reproducibility of NODDI metrics on empirical data in the context of acquisition protocol and brain anatomy. Previous studies addressed reproducibility across the 3  T scanners and within session and between subject reproducibility at 1.5 T and 3 T.

Source: Magnetic Resonance Imaging - March 8, 2018 Category: Radiology Authors: Prasanna Parvathaneni, Vishwesh Nath, Justin A. Blaber, Kurt G. Schilling, Allison E. Hainline, Ed Mojahed, Adam W. Anderson, Bennett A. Landman Tags: Original contribution Source Type: research