Genomic sequences of HLA ‐A*68:169, HLA‐B*07:298 and HLA‐B*39:129.

Summary
Three new HLA class I alleles were described in the Spanish population. HLA‐A*68:169 and ‐B*39:129 show one amino acid replacement at the α1‐domain, compared to A*68:02 (P47 > L47) and ‐B*39:06 (S11 > A11), respectively. HLA‐B*07:298 presents one nucleotide mutation within exon 1, resulting in a new amino acid position −14, L>Q, which has not been previously described in any HLA protein. Prediction of the B*07:298 signal peptide cleavage did not show significant differences in comparison with that obtained for the rest of HLA‐B genes.

Source: International Journal of Immunogenetics - March 8, 2018 Category: Genetics & Stem Cells Authors: A. Balas, D. Planelles, M. Rodr íguez‐Cebriá, N. Puig, J. L. Vicario Tags: SHORT COMMUNICATION Source Type: research