25 ‐Hydroxyvitamin D3‐enhanced PTPN2 positively regulates periodontal inflammation through the JAK/STAT pathway in human oral keratinocytes and a mouse model of type 2 diabetes mellitus

ConclusionPTPN2 contributed to a decrease in periodontal inflammation in type 2 diabetes mellitus via dephosphorylate protein substrates in the JAK1/STAT3 signaling pathway after 25VD3 treatment in human oral keratinocytes and a mouse model of type 2 diabetes mellitus. A thorough understanding of PTPN2 and its involvement in inhibiting inflammation might provide alternative therapeutic approaches for the pathogenesis and treatment of diabetes mellitus‐associated periodontitis.

Source: Journal of Periodontal Research - March 8, 2018 Category: Dentistry Authors: P. Zhang, W. Zhang, D. Zhang, M. Wang, R. Aprecio, N. Ji, O. Mohamed, Y. Li, Y. Ding, Q. Wang Tags: ORIGINAL ARTICLE Source Type: research