Ago2 and Dicer1 are involved in METH ‐induced locomotor sensitization in mice via biogenesis of miRNA

In conclusion, this study indicates that miRNA biogenesis (such as Ago2 and Dicer1) and their miRNA products may have a role in the development of METH addiction. miRNA biogenesis (Ago2 and Dicer1) and their miRNA products may have a role in methamphetamine (METH) addiction. miRNAs and Ago2 were significantly down‐regulated, while pre‐miRNA remained unchanged or up‐regulated, which suggests that the down‐regulation of miRNAs was likely due to a reduction in Ago2‐mediated splicing. Dicer1 was significantly increased and was a potential target of METH‐induced decreased miRNAs such as miR‐124, miR‐212 and miR‐29b. Our study revealed a homeostasis mechanism between miRNA biogenesis and its interacting miRNAs in response to METH.
Source: Addiction Biology - Category: Addiction Authors: Tags: Original Article Source Type: research