Acute-phase proteins and iron status in cats with chronic kidney disease

Chronic kidney disease (CKD) affects approximately 15 to 30% of geriatric cats. The role of inflammation in this disease is not well characterized. In human patients, chronic inflammation and oxidative stress play key roles in the development and progression of CKD. Increased concentrations of positive acute-phase proteins (APPs), such as C-reactive protein (CRP), and inflammatory cytokines, such as interleukin (IL)-6, have been described in humans with CKD and are associated with poor outcome. Anemia also is considered a negative prognostic factor in humans with renal failure, and evidence suggests that the severity of anemia is directly related to the progression of renal disease.
Source: Advances in Small Animal Medicine and Surgery - Category: Veterinary Research Tags: Nephrology/Urology Source Type: research