CSF levels of phosphorylated neurofilament heavy as a diagnostic marker of canine degenerative myelopathy

Canine degenerative myelopathy (DM) is a late-onset progressive neurodegenerative disease affecting many pure and mixed-breed dogs. The clinical spectrum of DM is homogeneous within and across breeds. Four stages of disease progression have been defined. Clinical signs are the result of multisystem neurodegeneration, resulting from progressive axonal degeneration of the central and peripheral nervous systems. Superoxide dismutase 1 gene (SOD1) mutations are risk factors for DM, with most cases resulting from autosomal recessive inheritance.
Source: Advances in Small Animal Medicine and Surgery - Category: Veterinary Research Tags: Neurology Source Type: research