MAPK-activated protein kinase 2-deficiency causes hyperacute tumor necrosis factor-induced inflammatory shock

Conclusions:
The capacity of the endothelial barrier to deal with inflammatory and oxidative stress is imperative to allow a regulated immune response and maintain endothelial barrier integrity. Our results indicate that, considering the central role of TNF in pro-inflammatory signaling, therapeutic strategies examining pharmacological inhibition of MK2 should take potentially dangerous side effects at the level of endothelial barrier integrity into account.

Source: BMC Physiology - Latest articles - September 4, 2014 Category: Physiology Authors: Benjamin VandendriesscheAn GoethalsAlba SimatsEvelien Van HammePeter BrouckaertAnje Cauwels Source Type: research