Allopurinol Dose Escalation and Mortality among Patients with Gout: A National Propensity ‐Matched Cohort Study

ConclusionThis is the largest study of allopurinol's effect on mortality and the first to use a rigorous active‐comparator design. Dose escalation was associated with a small (<10%) increase in all‐cause mortality, showing that allopurinol dose escalation is unlikely to improve survival as currently prescribed in real life practice characterized by limited dose increases.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - Category: Rheumatology Authors: Tags: Full Length Source Type: research