Growth Differentiation Factor 11 Promotes Abnormal Proliferation and Angiogenesis of Pulmonary Artery Endothelial CellsNovelty and Significance [Pulmonary Hypertension]

This study identified a novel growth and differentiation factor signaling pathway involved in the zinc finger protein 740/GDF11/transforming growth factor-β receptor I/Smad signaling axis and involved in pulmonary artery endothelial cells proliferation and angiogenesis. These results provide critical insights for the development of novel therapeutic strategies for pulmonary arterial hypertension involving components of the GDF11 signaling system.

Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Xiufeng Yu, Xinxin Chen, Xiao Dong Zheng, Junting Zhang, Xijuan Zhao, Ying Liu, Hongyue Zhang, Lixin Zhang, Hao Yu, Min Zhang, Cui Ma, Xuewei Hao, Daling Zhu Tags: Pulmonary Hypertension Original Articles Source Type: research