Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone’s Antifibrotic ActivityNovelty and Significance [Mineralocorticoid Receptor]

This study demonstrates that the nonsteroidal MRA finerenone potently prevents cardiac fibrosis and improves strain parameters in mice. Cardiac antifibrotic actions of finerenone may result from the inhibition of profibrotic TNX gene expression mediated by differential MR cofactor binding. Selective MR cofactor modulation provides a molecular basis for distinct (pre)-clinical actions of nonsteroidal and steroidal MRAs.

Source: Hypertension - March 7, 2018 Category: Cardiology Authors: Jana Grune, Niklas Beyhoff, Elia Smeir, Remigiusz Chudek, Annelie Blumrich, Zsofia Ban, Sarah Brix, Iris R. Betz, Michael Schupp, Anna Foryst–Ludwig, Robert Klopfleisch, Philipp Stawowy, Rene Houtman, Peter Kolkhof, Ulrich Kintscher Tags: Fibrosis, Heart Failure, Remodeling Original Articles Source Type: research