Meta-analysis of Tpeak –Tend and Tpeak–Tend/QT ratio for risk stratification in congenital long QT syndrome

Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death. The Tpeak –Tend interval and the Tpeak–Tend/QT ratio, electrocardiographic markers of dispersion of ventricular repolarization, were proposed for risk stratification but their predictive values in LQTS have been controversial. A systematic review and meta-analysis was conducted to examine the value of Tpe ak–Tend intervals and Tpeak–Tend/QT ratios in predicting arrhythmic and mortality outcomes in congenital LQTS.

Source: Journal of Electrocardiology - March 6, 2018 Category: Cardiology Authors: Gary Tse, Mengqi Gong, Lei Meng, Cheuk Wai Wong, Stamatis Georgopoulos, George Bazoukis, Martin C.S. Wong, Konstantinos P. Letsas, Vassilios S. Vassiliou, Yunlong Xia, Adrian M. Baranchuk, Gan-Xin Yan, Tong Liu Source Type: research