Tandem tyrosine phosphosites in the enteropathogenic Escherichia coli chaperone CesT are required for differential type III effector translocation and virulence
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Pathogens with type III secretion systems (T3SS) absolutely require dedicated chaperone proteins to mediate efficient effector protein injection into host cells during infection. In this study, we implicate tandem tyrosine phosphosites of CesT in differentially regulating effector secretion and contributing to intestinal disease. These findings expand the functional importance of CesT in context of bacterial pathogenesis, revealing an unexpected phosphosite specificity for a T3SS chaperone.
Source: Molecular Microbiology - Category: Microbiology Authors: Cameron S. Runte, Umang Jain, Landon J. Getz, Sabrina Secord, Asaomi Kuwae, Akio Abe, Jason J. LeBlanc, Andrew W. Stadnyk, James B. Kaper, Anne ‐Marie Hansen, Nikhil A. Thomas Tags: Research Article Source Type: research