The Taming of the Maleimide: Fabrication of Maleimide ‐containing ‘Clickable’ Polymeric Materials

Abstract
Functional polymers are widely employed in various areas of biomedical sciences. In order to tailor them for desired applications, facile and efficient functionalization of these polymeric materials under mild and benign conditions is important. Polymers containing reactive maleimide groups can be employed for such applications since they provide an excellent handle for conjugation of thiol‐ and diene‐containing molecules and biomolecules. Until recently, fabrication of maleimide containing polymeric materials has been challenging due to the interference from the highly reactive double bond. A Diels‐Alder/retro Diels‐Alder reaction sequence based strategy to transiently mask the maleimide group provides access to such polymeric materials. In this personal account, we summarize contributions from our group towards the fabrication and functionalization of maleimide‐containing polymeric materials over the past decade.

In this account, we describe our research group's contribution towards fabrication and functionalization of maleimide‐containing polymeric materials over the past decade. A Diels‐Alder/retro Diels‐Alder reaction sequence based strategy provides facile access to these ‘clickable’ materials which are potential candidates for various applications in biomedical sciences.

Source: Contrast Media and Molecular Imaging - December 29, 2017 Category: Radiology Authors: Yavuz Oz, Amitav Sanyal Tags: Personal Account Source Type: research