Network Measures for Chemical Library Design
Abstract
In this overview, we examine recent developments in network approaches to drug design. A brief overview of networks is followed by a discussion of how chemical similarity networks and their properties address challenges in drug design. Multiple methods used to assess or enhance chemical diversity for early‐stage drug discovery are discussed, as well as methods that can be used for drug repositioning and ligand polypharmacology.
Source: Drug Development Research - Category: Drugs & Pharmacology Authors: Nagamani Sukumar, Michael P. Krein, Ganesh Prabhu, Sudeepto Bhattacharya, Subhabrata Sen Tags: Research Overview Source Type: research