Chronic treatment with URB597 ameliorates post-stress symptoms in a rat model of PTSD

We examined whether chronic treatment with the fatty acid amide hydrolase (FAAH) inhibitor URB597 (0.2, 0.3, 0.4  mg/kg, i.p.) or the CB1/2 receptor agonist WIN55,212-2 (0.25, 0.5 mg/kg, i.p.) injected for 3 weeks to rats exposed to the shock and reminders model of PTSD would attenuate post-stress symptoms and affect basolateral amygdala (BLA) and CA1 CB1 receptors.

Source: European Neuropsychopharmacology - March 5, 2018 Category: Psychiatry & Psychology Authors: Sharon Fidelman, Tomer Mizrachi Zer-Aviv, Rachel Lange, Cecilia J. Hillard, Irit Akirav Source Type: research