Evaluation of 177Lu- CHX-A ´´-DTPA-6A10 Fab as a Radioimmunotherapy Agent Targeting Carbonic Anhydrase XII

Due to their infiltrative growth behavior, gliomas have, even after surgical resection, a high recurrence tendency. The approach of intracavitary radioimmunotherapy (RIT) is aimed at inhibiting tumor re-growth by directly administering drugs into the resection cavity (RC). Direct application of the radioconjugate into the RC has the advantage of bypassing the blood-brain barrier, which allows the administration of higher radiation doses than systemic application. Carbonic anhydrase XII (CA XII) is highly expressed on glioma cells while being absent from normal brain and thus an attractive target molecule for RIT.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research