Robust high-yield ~1 TBq production of cyclotron based sodium [99mTc]pertechnetate

This paper presents the irradiation and processing of high-current 100Mo targets at the University of Alberta (UofA) in a GMP compliant setting. For purpose of comparison with a second production facility, additional studies at Centre Hospitalier Universitaire de Sherbrooke (CHUS) are also described. Introduction:>70% of today's diagnostic radiopharmaceuticals are based on 99mTc, however the conventional supply chain for obtaining 99mTc is fragile. The aim of this work was to demonstrate reliable high yield production and processing of 99mTc with medium-energy, high-current, cyclotrons.

Source: Nuclear Medicine and Biology - March 2, 2018 Category: Nuclear Medicine Authors: J.D. Andersson, B. Thomas, S.V. Selivanova, E. Berthelette, J.S. Wilson, A.J.B. McEwan, K. Gagnon Source Type: research