Activation of RhoA, Smad2, c ‐Src, PKC‐βII/δ and JNK in atopic dermatitis

Abstract
Atopic dermatitis is a multifactorial skin disease characterised by chronic and relapsing inflammation whose pathogenesis is incompletely understood. We found that the expression of TGFβR1 and the activation of SMAD2, RhoA, JNK, PKC‐βII/δ and c‐Src were upregulated in the infiltrated inflammatory cells, fibroblasts and vasculatures in the dermis and epidermis. In addition, increases in the expression of TGFβR1 and phosphorylation levels of JNK and c‐Src were positively correlated with the inflammatory progression of atopic dermatitis severity.

Source: Australasian Journal of Dermatology - February 1, 2018 Category: Dermatology Authors: Jianyun Lu, Rong Yin, Zhibing Fu, Veronica M Lee, John Stuart Nelson, Wenbin Tan Tags: Brief Reports Source Type: research