Sphingosine ‐1‐phosphate receptors and innate immunity

Abstract
Sphingosine‐1‐phosphate (S1P) is a signaling lipid that regulates many cellular processes in mammals. One well‐studied role of S1P signaling is to modulate T‐ cell trafficking, which has a major impact on adaptive immunity. Compounds that target S1P signaling pathways are of interest for immune system modulation. Recent studies suggest that S1P signaling regulates many more cell types and processes than previously appreciated. This review will summarize current understanding of S1P signaling, focusing on recent novel findings in the roles of S1P receptors in innate immunity.

Source: Cellular Microbiology - March 1, 2018 Category: Microbiology Authors: Arielle M. Bryan, Maurizio Del Poeta Tags: MICROREVIEW Source Type: research