Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells

The mouse olfactory neuroepithelium (ON) is comprised of anatomically distinct populations of cells in separate regions; apical (sustentacular and microvillar), neuronal (olfactory sensory neurons) and basal (horizontal and globose basal cells). The existence of microvillar cells (MVCs) is well documented but their nature and function remains unclear. An important transcription factor for the differentiation of MVCs is Skn-1a, with loss of function of Skn-1a in mice resulting in a complete loss of Trpm-5 expressing MVCs, while olfactory sensory neuron differentiation is normal.

Source: Neuropeptides - March 1, 2018 Category: Neuroscience Authors: Kharen L. Doyle, Carla Cunha, Yvonne Hort, Ramon Tasan, G ünther Sperk, John Shine, Herbert Herzog Source Type: research