Genetic diversity of Mycobacterium tuberculosis isoniazid monoresistant and multidrug-resistant in Rio Grande do Sul, a tuberculosis high-burden state in Brazil

Tuberculosis (TB) remains a major public health problem in the world and Brazil is among the countries with the highest incidence and prevalence rates, and Rio Grande do Sul, a Brazilian state, occupy a prominent position. Multidrug-resistant Mycobacterium tuberculosis (MDR-TB) further aggravates this scenario, making it more difficult to treat and control the disease. Isoniazid monoresistance (IMR) may increase the risk of progression to MDR-TB and treatment failure. However, most drug resistance molecular tests only focus on detecting rifampicin (RIF) resistance.In the present study, we characterized a total of 63 drug resistant isolates of M.

Source: Tuberculosis - March 1, 2018 Category: Respiratory Medicine Authors: Leonardo Souza Esteves, Elis Regina Dalla Costa, Sidra Ezidio Gon çalves Vasconcellos, Andrei Vargas, Sérgio Luis Montego Ferreira Junior, Maria Laura Halon, Marta Osorio Ribeiro, Rodrigo Rodenbusch, Harrison Magdinier Gomes, Philip N. Suffys, Maria Luc Source Type: research