Long‐term dexamethasone treatment alters the histomorphology of acinar cells in rat parotid and submandibular glands
In conclusion, the long‐term administration of dexamethasone caused IR, which was associated with significant reductions in both mass and flux rate of the salivary glands. The parotid and submandibular glands exhibited reduced acinar cell volume; however, the submandibular glands displayed acinar hyperplasia, indicating a gland‐specific response to GCs. Our data emphasize that GC‐based therapies and insulin‐resistant states have a negative impact on salivary gland homeostasis.
Source: International Journal of Experimental Pathology - Category: Pathology Authors: Bruna B. Bighetti, Gerson F. Assis, Danilo C. Vieira, Natalia M. Violato, Tania M. Cestari, Rumio Taga, José R. Bosqueiro, Alex Rafacho Tags: Original Article Source Type: research