[Comment] Clinical trials in older, less fit populations: an unmet need?

Hans Wildiers and colleagues1 are to be congratulated on their demonstration of a framework for clinical trials in older, more frail patients with HER-positive metastatic breast cancer. Clinical trials are a global prerequisite for establishing new treatment standards, but eligibility criteria generally restrict participation to fit populations with minimal comorbidities. These criteria contribute to underrepresentation of older populations with functional limitations in most clinical trials.
Source: The Lancet Oncology - Category: Cancer & Oncology Authors: Tags: Comment Source Type: research