Induction chemotherapy followed by concurrent chemoradiation versus concurrent chemoradiation alone in the definitive management of p16-positive oropharyngeal squamous cell carcinoma with low-neck or N3 disease

Concurrent chemoradiation (CCRT) is the standard of care for locally advanced head and neck squamous cell carcinoma (LAHNSCC) [1 –3]. The addition of induction chemotherapy (ICT) to CCRT has been investigated as a method of further improving outcomes among these patients, but its application remains controversial. Several randomized clinical trials have performed a comparison of ICT followed by CCRT to CCRT alone in LAHNSCC ; the majority of these studies have not demonstrated a survival benefit with the addition of ICT [4–8].

Source: Oral Oncology - February 3, 2018 Category: Cancer & Oncology Authors: Onita Bhattasali, Jeannie Han, Lester D.R. Thompson, Gary L. Buchschacher, Iman A. Abdalla, Shawn Iganej Source Type: research