Comparison of clinical, radiological and morphological features including the distribution of HPV E6/E7 oncogenes in resection specimens of oropharyngeal squamous cell carcinoma

Human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is acknowledged as a distinct entity in the 4th edition of the WHO/IARC Classification of Head and Neck Tumours and in the 8th edition of the UICC TNM Staging Manual [1,2]. The rationale behind these major changes is based on the numerous studies published during the past two decades, establishing a unique and distinct tumour type of HPV-driven OPSCC in terms of anatomy, pathology and clinical profile. The E6 and E7 oncogenes are considered as the driving factors of HPV-driven OPSCC, and they are essential in distinguishing between non-active HPV infection and transcriptionally active HPV infection [3 –6].

Source: Oral Oncology - February 6, 2018 Category: Cancer & Oncology Authors: Hani Ibrahim Channir, Katalin Kiss, Niclas Rubek, Jane Andersen, Jeanette B æhr Georgsen, Gulla Søby Rathje, Birgitte Wittenborg Charabi, Christian von Buchwald, Christel Bræmer Lajer Source Type: research