Phosphorylation of PI3K regulatory subunit p85 contributes to resistance against PI3K inhibitors in radioresistant head and neck cancer

Phosphatidylinositol 3 –kinase (PI3K)/AkT/mTOR axis regulates essential cellular functions, including cell metabolism, growth, migration, survival, and angiogenesis [1,2]. PI3K pathway activation is commonly observed in different cancers and is correlated with tumor development, progression, poor prognosis, and resistan ce to cancer therapies, including radiotherapy and chemotherapy [3–5]. Class IA PI3K is a heterodimeric protein containing a catalytic subunit (p110) and a regulatory subunit (p85).

Source: Oral Oncology - February 11, 2018 Category: Cancer & Oncology Authors: Myung Woul Han, In Sun Ryu, Jong Cheol Lee, Song Hee Kim, Hyo Won Chang, Yoon Sun Lee, Seulkina Lee, Seong Who Kim, Sang Yoon Kim Source Type: research