A revised model for the control of fatty acid synthesis by master regulator Spo0A in Bacillus subtilis

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The fatty acid metabolism operon accDA is controlled by the master regulator Spo0A and a fluorescent fusion to its gene product AccA forms discrete puncta at the cell membrane in Bacillus subtilis. Here we demonstrate that the fine‐tuning of fatty acid synthesis via Spo0A and the essential enzyme acetyl‐CoA carboxylase is required for timely sporulation and the proper construction of biofilms.

Source: Molecular Microbiology - February 28, 2018 Category: Microbiology Authors: Lindsey Haggett, Archna Bhasin, Priyanka Srivastava, Masaya Fujita Tags: Research Article Source Type: research