Plasma kallikrein activates the epithelial sodium channel (ENaC) in vitro but is not essential for volume retention in nephrotic mice

ConclusionPKLK is detected in the urine of proteinuric patients and mice and activates ENaC in vitro involving the putative prostasin cleavage site. However, PKLK is not essential for volume retention in nephrotic mice.This article is protected by copyright. All rights reserved.

Source: Acta Physiologica - February 28, 2018 Category: Physiology Authors: Silke Haerteis, Anja Schork, Thomas D örffel, Bernhard N. Bohnert, Regina Nacken, Matthias Wörn, Mengyun Xiao, Daniel Essigke, Andrea Janessa, Alvin H. Schmaier, Edward P. Feener, Hans‐Ulrich Häring, Marko Bertog, Christoph Korbmacher, Ferruh Artunc Tags: Regular Paper Source Type: research