A High ‐Fat Diet Rich in Saturated and Mono‐Unsaturated Fatty Acids Induces Disturbance of Thyroid Lipid Profile and Hypothyroxinemia in Male Rats

ConclusionExcess intake of dietary fat induces disturbance of thyroid lipid profile and hypothyroxinemia, indicating thyroid dysfunction. We speculate that it may provide a new prospect in understanding the pathogenesis of hypothyroidism. Male SD rats were fed with a high‐fat diet (HFD) rich in saturated and mono‐unsaturated fatty acids or chow diet for 18 weeks. LC‐MS analysis of thyroid glands show that HFD interfered with the concentration of FFAs, the composition of fatty acids in triglycerides (TGs), and some other lipid molecules. HFD rats also show hypothyroxinemia, decreased iodine uptake, and downregulation of hepatic T3‐responsive genes.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmnfr.201700599

Source: Nahrung / Food - February 28, 2018 Category: Nutrition Authors: Xiaohan Zhang, Wenbin Chen, Shanshan Shao, Guowang Xu, Yongfeng Song, Chao Xu, Ling Gao, Chunxiu Hu, Jiajun Zhao Tags: RESEARCH ARTICLE Source Type: research