Inhibition of ZERO ‐BK by PKC is involved in carbachol‐induced enhancement of rat colon smooth muscle motility

ConclusionOur results provide strong evidence that inhibition of ZERO‐BK but not STREX‐BK channels via PKC pathway is involved in the enhancement of CSM motility by mAChR activation. Besides the activation of BK by an increase in intracellular calcium, inhibition of BK played an important role in GI motility regulation during mAChR activation. BK channels were involved in basic and carbachol‐induced contraction regulation of GI strips. Only ZERO‐BK channels were inhibited by PKC which took part in carbachol‐induced motility enhancement in rat CSM.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fnmo.13312

Source: Neurogastroenterology and Motility - February 28, 2018 Category: Gastroenterology Authors: F. Xin, H. Huang, P. Liu, J. Ren, S. Zhang, Y. Cheng, W. Wang Tags: ORIGINAL ARTICLE Source Type: research