Biochemical transformation of calciprotein particles in uraemia

Calciprotein particles (CPP) have emerged as nanoscale mediators of phosphate-induced toxicity in Chronic Kidney Disease (CKD). Uraemia favors ripening of amorphous CPP (CPP-I) to the crystalline state (CPP-II) but the pathophysiological significance of this transformation is uncertain. Clinical studies suggest an association between CPP ripening and inflammation, vascular dysfunction and mortality. Although ripening has been modelled in vitro, it is unknown whether particles synthesised in serum resemble their in vivo counterparts.

Source: Bone - February 27, 2018 Category: Orthopaedics Authors: Edward R. Smith, Tim D. Hewitson, Eric Hanssen, Stephen G. Holt Tags: Full Length Article Source Type: research