Microvasospasms After Experimental Subarachnoid Hemorrhage Do Not Depend on Endothelin A Receptors [Basic Sciences]

Conclusions—Our results indicate that ETA receptors, which mediate large artery spasms after SAH, do not seem to play a role in the development of microarterial spasms, suggesting that posthemorrhagic spasms are mediated by distinct mechanisms in large and small cerebral vessels. Given that cerebral microvessel dysfunction is a key factor for outcome after SAH, further research into the mechanisms that underlie posthemorrhagic microvasospasms is urgently needed.

Source: Stroke - February 26, 2018 Category: Neurology Authors: Hanhan Liu, Ari Dienel, Karsten Scholler, Susanne M. Schwarzmaier, Kathrin Nehrkorn, Nikolaus Plesnila, Nicole A. Terpolilli Tags: Basic Science Research, Mechanisms, Pathophysiology, Translational Studies, Cerebrovascular Disease/Stroke Original Contributions Source Type: research