Hyphal induction under the condition without inoculation in Candida albicans is triggered by Brg1 ‐mediated removal of NRG1 inhibition

This article is protected by copyright. All rights reserved. Candida albicans, a major opportunistic fungal pathogen of humans, can switch between yeast and hyphae growth forms, which is critical for its pathogenesis. GlcNAc (N‐acetylglucosamine)‐induced hyphal growth in log phase cells requires Ngs1 (GlcNAc sensor)‐mediated activation of BRG1 expression, which down‐regulates NRG1 transcript. Hyphal development induced by serum or neutral pH under the condition without inoculation is also triggered by Brg1‐mediated removal of Nrg1 inhibition.
Source: Molecular Microbiology - Category: Microbiology Authors: Tags: Research Article Source Type: research